3H2P
Human SOD1 D124V Variant
Summary for 3H2P
Entry DOI | 10.2210/pdb3h2p/pdb |
Related | 3H2Q 3H2R |
Descriptor | Superoxide dismutase [Cu-Zn], ZINC ION, MALONATE ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase, human cu, zn superoxide dismutase, antioxidant, metal-binding, copper, zinc, amyotrophic lateral sclerosis, disease mutation, acetylation, cytoplasm, disulfide bond, phosphoprotein, ubl conjugation |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00441 |
Total number of polymer chains | 2 |
Total formula weight | 32067.58 |
Authors | Seetharaman, S.V.,Winkler, D.D.,Taylor, A.B.,Cao, X.,Whitson, L.J.,Doucette, P.A.,Valentine, J.S.,Carroll, M.C.,Culotta, V.C.,Hart, P.J. (deposition date: 2009-04-14, release date: 2010-05-05, Last modification date: 2023-09-06) |
Primary citation | Seetharaman, S.V.,Winkler, D.D.,Taylor, A.B.,Cao, X.,Whitson, L.J.,Doucette, P.A.,Valentine, J.S.,Carroll, M.C.,Culotta, V.C.,Hart, P.J. Structures of Pathogenic SOD1 Mutants H80R and D124V: Disrupted Zinc-binding and Compromised Post-translational Modification by the Copper Chaperone CCS To be Published, |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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