3H0J
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 2
Summary for 3H0J
Entry DOI | 10.2210/pdb3h0j/pdb |
Related | 3H0Q 3H0S |
Descriptor | Acetyl-CoA carboxylase, 6-{[1-(anthracen-9-ylcarbonyl)piperidin-4-yl]methyl}-2-methylquinoline (2 entities in total) |
Functional Keywords | transferase, acetyl-coa carboxylase, carboxyltransferase, inhibitor, acc, ct, atp-binding, biotin, cytoplasm, fatty acid biosynthesis, ligase, lipid synthesis, metal-binding, multifunctional enzyme, nucleotide-binding |
Biological source | Saccharomyces cerevisiae (yeast) |
Cellular location | Cytoplasm: Q00955 |
Total number of polymer chains | 3 |
Total formula weight | 263047.63 |
Authors | |
Primary citation | Corbett, J.W.,Freeman-Cook, K.D.,Elliott, R.,Vajdos, F.,Rajamohan, F.,Kohls, D.,Marr, E.,Zhang, H.,Tong, L.,Tu, M.,Murdande, S.,Doran, S.D.,Houser, J.A.,Song, W.,Jones, C.J.,Coffey, S.B.,Buzon, L.,Minich, M.L.,Dirico, K.J.,Tapley, S.,McPherson, R.K.,Sugarman, E.,Harwood, H.J.,Esler, W. Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg.Med.Chem.Lett., 20:2383-2388, 2010 Cited by PubMed: 20219367DOI: 10.1016/j.bmcl.2009.04.091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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