3GRW

FGFR3 in complex with a Fab

Summary for 3GRW

Entry DOI	10.2210/pdb3grw/pdb
Descriptor	Fibroblast growth factor receptor 3, Fab light chain, Fab heavy chain, ... (6 entities in total)
Functional Keywords	fgfr3, fab, protein-protein complex, receptor tyrosine kinase, atp-binding, immunoglobulin domain, kinase, membrane, nucleotide-binding, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-immune system complex, transferase/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	75436.03
Authors	Wiesmann, C. (deposition date: 2009-03-26, release date: 2009-05-05, Last modification date: 2020-07-29)
Primary citation	Qing, J.,Du, X.,Chen, Y.,Chan, P.,Li, H.,Wu, P.,Marsters, S.,Stawicki, S.,Tien, J.,Totpal, K.,Ross, S.,Stinson, S.,Dornan, D.,French, D.,Wang, Q.R.,Stephan, J.P.,Wu, Y.,Wiesmann, C.,Ashkenazi, A. Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice. J.Clin.Invest., 119:1216-1229, 2009 Cited by PubMed: 19381019 DOI: 10.1172/JCI38017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation