3G03
Structure of human MDM2 in complex with high affinity peptide
Summary for 3G03
| Entry DOI | 10.2210/pdb3g03/pdb |
| Related | 1T4F 1YCR 3FDO |
| Descriptor | E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide (3 entities in total) |
| Functional Keywords | mdm2, hdm2, mdmx, hdmx, mdm4, p53, cancer, apoptosis, cell cycle, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 28152.22 |
| Authors | Czarna, A.L.,Popowicz, G.M.,Holak, T.A. (deposition date: 2009-01-27, release date: 2009-04-14, Last modification date: 2023-11-01) |
| Primary citation | Czarna, A.,Popowicz, G.M.,Pecak, A.,Wolf, S.,Dubin, G.,Holak, T.A. High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8:1176-1184, 2009 Cited by PubMed: 19305137DOI: 10.4161/cc.8.8.8185 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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