3FSF
P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
Summary for 3FSF
Entry DOI | 10.2210/pdb3fsf/pdb |
Related | 3FLN 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN |
Descriptor | Mitogen-activated protein kinase 14, 3-(2,6-dichlorophenyl)-7-({4-[(diethylamino)methoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (3 entities in total) |
Functional Keywords | p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 43250.12 |
Authors | Kuglstatter, A.,Bertrand, J.,Lovejoy, B. (deposition date: 2009-01-09, release date: 2009-12-22, Last modification date: 2023-09-06) |
Primary citation | Soth, M.,Kuglstatter, A.,Goldstein, D. The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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