3FKT
Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
Replaces: 3E3WSummary for 3FKT
Entry DOI | 10.2210/pdb3fkt/pdb |
Descriptor | Beta-secretase 1, N-(4-{[4-(cyclohexylamino)-1-(3-fluorophenyl)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-8-yl]methyl}phenyl)acetamide (3 entities in total) |
Functional Keywords | aspartyl protease, bace, alternative splicing, glycoprotein, hydrolase, membrane, polymorphism, protease, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45614.35 |
Authors | Munshi, S. (deposition date: 2008-12-17, release date: 2009-01-20, Last modification date: 2023-09-06) |
Primary citation | Barrow, J.C.,Stauffer, S.R.,Rittle, K.E.,Ngo, P.L.,Yang, M.S.,Graham, S.,McGaughey, G.,Holloway, K.,Tugusheva, S.K.,Lai, M.,Espeseth, A.S.,Xu, M.,Huang, Q.,Zuck, P.,Levorse, D.A.,Hazuda, D.,Vacca, J.P. Discovery and X-ray Crystallographic Analysis of a Iminohydantoin Inhibitor of beta-Secretase J.Med.Chem., 51:6259-6262, 2008 Cited by PubMed: 18811140DOI: 10.1021/jm800914n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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