3FKL

P38 kinase crystal structure in complex with RO9552

Summary for 3FKL

• Entry DOI: 10.2210/pdb3fkl/pdb
• Related: 3FI4 3FKN 3FKO
• Descriptor: Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[8-methyl-7-oxo-2-(tetrahydro-2H-pyran-4-ylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]benzamide (3 entities in total)
• Functional Keywords: p38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43182.22

Authors

Kuglstatter, A.,Ghate, M. (deposition date: 2008-12-17, release date: 2009-12-22, Last modification date: 2023-09-06)

• Primary citation: Arora, N.,Williams, C.,Delano, W.,Will, D.,Kuglstatter, A.; Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)