3EWH
Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor
Summary for 3EWH
Entry DOI | 10.2210/pdb3ewh/pdb |
Related | 3EFW |
Descriptor | vascular endothelial growth factor receptor 2, N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | angiogenesis, receptor tyrosine kinase, dfg-out, transferase |
Biological source | Homo sapiens More |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 36714.20 |
Authors | Whittington, D.A.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2008-10-15, release date: 2009-08-25, Last modification date: 2023-12-27) |
Primary citation | Cee, V.J.,Cheng, A.C.,Romero, K.,Bellon, S.,Mohr, C.,Whittington, D.A.,Bak, A.,Bready, J.,Caenepeel, S.,Coxon, A.,Deak, H.L.,Fretland, J.,Gu, Y.,Hodous, B.L.,Huang, X.,Kim, J.L.,Lin, J.,Long, A.M.,Nguyen, H.,Olivieri, P.R.,Patel, V.F.,Wang, L.,Zhou, Y.,Hughes, P.,Geuns-Meyer, S. Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase. Bioorg.Med.Chem.Lett., 19:424-427, 2009 Cited by PubMed: 19062275DOI: 10.1016/j.bmcl.2008.11.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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