3EN4
Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor
Summary for 3EN4
Entry DOI | 10.2210/pdb3en4/pdb |
Related | 3EN5 3EN6 3EN7 |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | src, tyrosine, kinase, polypharmacology, inhibitor, multitarget, phosphoinositide, transferase, signaling, pyrazolopyrimidine, kinase-inhibitor complex, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, tyrosine-protein kinase |
Biological source | Gallus gallus (bantam,chickens) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66092.02 |
Authors | Blair, J.A.,Apsel, B.,Knight, Z.A.,Shokat, K.M. (deposition date: 2008-09-25, release date: 2008-10-14, Last modification date: 2023-09-06) |
Primary citation | Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol., 4:691-699, 2008 Cited by PubMed: 18849971DOI: 10.1038/nchembio.117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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