3EM4

Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease

3EM4 の概要

• エントリーDOI: 10.2210/pdb3em4/pdb
• 関連するPDBエントリー: 3EM3 3EM6
• 分子名称: Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: drug resistance, hypersusceptibility, protease inhibitor, hiv, atazanavir, aids, hydrolase, protease
• 由来する生物種: HIV-1 M:B_ARV2/SF2 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 45393.77

構造登録者

Prabu-Jeyabalan, M.,King, N.,Royer, C.,Schiffer, C. (登録日: 2008-09-23, 公開日: 2009-09-01, 最終更新日: 2024-03-13)

• 主引用文献: Prabu-Jeyabalan, M.,King, N.,Bandaranayake, R.,Nalivaika, E.,Schiffer, C.; Kinetic and Structural studies on atazanavir-specific I50L drug-resistant HIV-1 protease mutant; To be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)