3DS9

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate

Summary for 3DS9

• Entry DOI: 10.2210/pdb3ds9/pdb
• Related: 1XTF 2ISG 3DSE
• Descriptor: Botulinum neurotoxin type A, octapeptide I1 inhibitor, ZINC ION, ... (5 entities in total)
• Functional Keywords: snare, botulism, inhibition, metalloprotease, neurotransmission, neuromuscular junction, hydrolase, membrane, metal-binding, neurotoxin, pharmaceutical, protease, secreted, toxin, transmembrane, zinc
• Biological source: Clostridium botulinum
• Cellular location: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• Total number of polymer chains: 2
• Total formula weight: 49032.34

Authors

Zuniga, J.E.,Fenn, T. (deposition date: 2008-07-11, release date: 2008-09-30, Last modification date: 2011-07-13)

• Primary citation: Zuniga, J.E.,Schmidt, J.J.,Fenn, T.,Burnett, J.C.,Arac, D.,Gussio, R.,Stafford, R.G.,Badie, S.S.,Bavari, S.,Brunger, A.T.; A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate; Structure, 16:1588-1597, 2008; PubMed: 18940613; DOI: 10.1016/j.str.2008.07.011

Experimental method

X-RAY DIFFRACTION (1.758 Å)