3DB4

Crystal structure of the tandem tudor domains of the E3 ubiquitin-protein ligase UHRF1

Summary for 3DB4

Entry DOI	10.2210/pdb3db4/pdb
Related	2FAZ 3BI7 3CLZ 3DB3
Descriptor	E3 ubiquitin-protein ligase UHRF1, SULFATE ION (3 entities in total)
Functional Keywords	cell cycle, dna damage, dna repair, tandem tudor domains, ligase, metal binding, dna replication, transcriptional silencing, chromatin, phosphorylation, transcription, transcription regulation, ubl conjugation pathway, zinc-finger, structural genomics, structural genomics consortium, sgc, dna-binding, metal-binding, nucleus, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q96T88
Total number of polymer chains	1
Total formula weight	19107.61
Authors	Walker, J.R.,Avvakumov, G.V.,Xue, S.,Dong, A.,Li, Y.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-05-30, release date: 2008-09-16, Last modification date: 2012-04-18)
Primary citation	Nady, N.,Lemak, A.,Walker, J.R.,Avvakumov, G.V.,Kareta, M.S.,Achour, M.,Xue, S.,Duan, S.,Allali-Hassani, A.,Zuo, X.,Wang, Y.X.,Bronner, C.,Chedin, F.,Arrowsmith, C.H.,Dhe-Paganon, S. Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J.Biol.Chem., 286:24300-24311, 2011 Cited by PubMed: 21489993 DOI: 10.1074/jbc.M111.234104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation