3D62

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

Summary for 3D62

Entry DOI	10.2210/pdb3d62/pdb
Descriptor	3C-like proteinase, benzyl (2-oxopropyl)carbamate (3 entities in total)
Functional Keywords	main protease 3clpro, sars, inhibitor, 95990, atp-binding, endonuclease, exonuclease, helicase, hydrolase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc-finger
Biological source	SARS coronavirus
Total number of polymer chains	1
Total formula weight	33407.15
Authors	Bacha, U.,Barrila, J.,Gabelli, S.B.,Kiso, Y.,Amzel, L.M.,Freire, E. (deposition date: 2008-05-18, release date: 2008-07-01, Last modification date: 2017-10-25)
Primary citation	Bacha, U.,Barrila, J.,Gabelli, S.B.,Kiso, Y.,Mario Amzel, L.,Freire, E. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem.Biol.Drug Des., 72:34-49, 2008 Cited by PubMed: 18611220 DOI: 10.1111/j.1747-0285.2008.00679.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation