3CST
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2
Summary for 3CST
| Entry DOI | 10.2210/pdb3cst/pdb |
| Related | 3CSF |
| Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Methylated Ruthenium Pyridocarbazole (2 entities in total) |
| Functional Keywords | phosphoinositide 3-kinase gamma, pi3k, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P48736 |
| Total number of polymer chains | 1 |
| Total formula weight | 111386.69 |
| Authors | Xie, P.,Marmorstein, R. (deposition date: 2008-04-10, release date: 2008-05-20, Last modification date: 2023-08-30) |
| Primary citation | Xie, P.,Williams, D.S.,Atilla-Gokcumen, G.E.,Milk, L.,Xiao, M.,Smalley, K.S.,Herlyn, M.,Meggers, E.,Marmorstein, R. Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. Acs Chem.Biol., 3:305-316, 2008 Cited by PubMed: 18484710DOI: 10.1021/cb800039y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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