3CQZ

Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin

Summary for 3CQZ

• Entry DOI: 10.2210/pdb3cqz/pdb
• Related: 1K83 2VUM
• Related PRD ID: PRD_000201
• Descriptor: DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4, ALPHA-AMANITIN, ... (13 entities in total)
• Functional Keywords: transcription-toxin complex, alpha amanitin, toxin, inhibitor, polymerase, transferase, dna binding, zinc-finger, phosphoprotein, transcription, transcription/toxin
• Biological source: SACCHAROMYCES CEREVISIAE (BREWER'S YEAST, LAGER BEER YEAST, YEAST); More
• Cellular location: Nucleus: P04050 P08518 P16370 P20434 P20436 P27999 P38902; Nucleus, nucleolus: P40422 P22139; Cytoplasm: P20435
• Total number of polymer chains: 11
• Total formula weight: 471088.25

Authors

Kaplan, C.D.,Larsson, K.-M.,Kornberg, R.D. (deposition date: 2008-04-03, release date: 2008-07-22, Last modification date: 2023-08-30)

• Primary citation: Kaplan, C.D.,Larsson, K.M.,Kornberg, R.D.; The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.; Mol.Cell, 30:547-, 2008; PubMed: 18538653; DOI: 10.1016/J.MOLCEL.2008.04.023

Experimental method

X-RAY DIFFRACTION (2.8 Å)