3CO3

X-Ray Crystal Structure of a Monofunctional Platinum-DNA Adduct, cis-{Pt(NH3)2(pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex

Summary for 3CO3

• Entry DOI: 10.2210/pdb3co3/pdb
• Descriptor: 5'-D(*DCP*DCP*DTP*DCP*DTP*DCP*DGP*DTP*DCP*DTP*DCP*DC)-3', 5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DGP*DAP*DGP*DAP*DGP*DG)-3', cis-diammine(pyridine)chloroplatinum(II), ... (4 entities in total)
• Functional Keywords: platinum-dna duplex, cisplatin, monofunctional pt compound, dna
• Total number of polymer chains: 2
• Total formula weight: 7670.48

Authors

Lovejoy, K.S.,Todd, R.C.,Zhang, S.,McCormick, M.S.,D'Aquino, J.A.,Reardon, J.T.,Sancar, A.,Giacomini, K.M.,Lippard, S.J. (deposition date: 2008-03-27, release date: 2008-06-10, Last modification date: 2024-02-21)

• Primary citation: Lovejoy, K.S.,Todd, R.C.,Zhang, S.,McCormick, M.S.,D'Aquino, J.A.,Reardon, J.T.,Sancar, A.,Giacomini, K.M.,Lippard, S.J.; cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.; Proc.Natl.Acad.Sci.Usa, 105:8902-8907, 2008; PubMed: 18579768; DOI: 10.1073/pnas.0803441105

Experimental method

X-RAY DIFFRACTION (2.16 Å)