3CJB

Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1

Summary for 3CJB

Entry DOI	10.2210/pdb3cjb/pdb
Related	3CJC
Descriptor	Actin, alpha skeletal muscle, Gelsolin, CALCIUM ION, ... (5 entities in total)
Functional Keywords	cross-linked dimer, atp-binding, cytoskeleton, methylation, muscle protein, nucleotide-binding, phosphoprotein, structural protein, actin capping, actin-binding, alternative initiation, amyloid, disease mutation, secreted
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton: P68135 Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396
Total number of polymer chains	2
Total formula weight	56756.12
Authors	Sawaya, M.R.,Kudryashov, D.S.,Pashkov, I.,Reisler, E.,Yeates, T.O. (deposition date: 2008-03-12, release date: 2008-03-25, Last modification date: 2024-02-21)
Primary citation	Kudryashov, D.S.,Durer, Z.A.,Ytterberg, A.J.,Sawaya, M.R.,Pashkov, I.,Prochazkova, K.,Yeates, T.O.,Loo, R.R.,Loo, J.A.,Satchell, K.J.,Reisler, E. Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. Proc.Natl.Acad.Sci.USA, 105:18537-18542, 2008 Cited by PubMed: 19015515 DOI: 10.1073/pnas.0808082105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.21 Å)

Structure validation