3CBR

Crystal structure of human Transthyretin (TTR) at pH3.5

Summary for 3CBR

• Entry DOI: 10.2210/pdb3cbr/pdb
• Related: 1BMZ
• Descriptor: Transthyretin (2 entities in total)
• Functional Keywords: ttr, amyloid, transthyretin, acidic ph, disease mutation, glycoprotein, hormone, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, vitamin a, transport protein, thyroxine binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 27554.72

Authors

Mohamedmohaideen, N.N.,Palaninathan, S.K.,Snee, W.C.,Kelly, J.W.,C Sacchettini, J. (deposition date: 2008-02-22, release date: 2008-08-12, Last modification date: 2023-08-30)

• Primary citation: Palaninathan, S.K.,Mohamedmohaideen, N.N.,Snee, W.C.,Kelly, J.W.,Sacchettini, J.C.; Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.; J.Mol.Biol., 382:1157-1167, 2008; PubMed: 18662699; DOI: 10.1016/j.jmb.2008.07.029

Experimental method

X-RAY DIFFRACTION (1.7 Å)