3C5U
P38 ALPHA map kinase complexed with a benzothiazole based inhibitor
Summary for 3C5U
Entry DOI | 10.2210/pdb3c5u/pdb |
Descriptor | Mitogen-activated protein kinase 14, 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, kinase, transferase, p38 map kinase, alternative splicing, atp-binding, cytoplasm, nucleotide-binding, nucleus, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42811.83 |
Authors | Sack, J.S. (deposition date: 2008-02-01, release date: 2008-03-25, Last modification date: 2024-02-21) |
Primary citation | Liu, C.,Lin, J.,Pitt, S.,Zhang, R.F.,Sack, J.S.,Kiefer, S.E.,Kish, K.,Doweyko, A.M.,Zhang, H.,Marathe, P.H.,Trzaskos, J.,Mckinnon, M.,Dodd, J.H.,Barrish, J.C.,Schieven, G.L.,Leftheris, K. Benzothiazole based inhibitors of p38alpha MAP kinase. Bioorg.Med.Chem.Lett., 18:1874-1879, 2008 Cited by PubMed: 18296051DOI: 10.1016/j.bmcl.2008.02.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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