3BM9
Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
Summary for 3BM9
Entry DOI | 10.2210/pdb3bm9/pdb |
Related | 3BMY |
Descriptor | Heat shock protein HSP 90-alpha, 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol (3 entities in total) |
Functional Keywords | chaperone, atp binding domain, alternative splicing, atp-binding, cytoplasm, nucleotide-binding, phosphoprotein, stress response |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 25734.68 |
Authors | Gopalsamy, A.,Shi, M.,Vogan, E.M.,Golas, J.,Jacob, J.,Johnson, J.,Lee, F.,Nilakantan, R.,Peterson, R.,Svenson, K.,Tam, M.S.,Wen, Y.,Chopra, R.,Ellingboe, J.,Arndt, K.,Boschelli, F. (deposition date: 2007-12-12, release date: 2008-07-08, Last modification date: 2024-02-21) |
Primary citation | Gopalsamy, A.,Shi, M.,Golas, J.,Vogan, E.,Jacob, J.,Johnson, M.,Lee, F.,Nilakantan, R.,Petersen, R.,Svenson, K.,Chopra, R.,Tam, M.S.,Wen, Y.,Ellingboe, J.,Arndt, K.,Boschelli, F. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J.Med.Chem., 51:373-375, 2008 Cited by PubMed: 18197612DOI: 10.1021/jm701385c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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