3BM9

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90

Summary for 3BM9

Entry DOI	10.2210/pdb3bm9/pdb
Related	3BMY
Descriptor	Heat shock protein HSP 90-alpha, 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol (3 entities in total)
Functional Keywords	chaperone, atp binding domain, alternative splicing, atp-binding, cytoplasm, nucleotide-binding, phosphoprotein, stress response
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	25734.68
Authors	Gopalsamy, A.,Shi, M.,Vogan, E.M.,Golas, J.,Jacob, J.,Johnson, J.,Lee, F.,Nilakantan, R.,Peterson, R.,Svenson, K.,Tam, M.S.,Wen, Y.,Chopra, R.,Ellingboe, J.,Arndt, K.,Boschelli, F. (deposition date: 2007-12-12, release date: 2008-07-08, Last modification date: 2024-02-21)
Primary citation	Gopalsamy, A.,Shi, M.,Golas, J.,Vogan, E.,Jacob, J.,Johnson, M.,Lee, F.,Nilakantan, R.,Petersen, R.,Svenson, K.,Chopra, R.,Tam, M.S.,Wen, Y.,Ellingboe, J.,Arndt, K.,Boschelli, F. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J.Med.Chem., 51:373-375, 2008 Cited by PubMed: 18197612 DOI: 10.1021/jm701385c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation