3AW0

Structure of SARS 3CL protease with peptidic aldehyde inhibitor

Summary for 3AW0

• Entry DOI: 10.2210/pdb3aw0/pdb
• Related: 3ATW 3AVZ 3AW1
• Related PRD ID: PRD_001000
• Descriptor: 3C-Like Proteinase, peptide ACE-SER-ALA-VAL-LEU-HIS-H (3 entities in total)
• Functional Keywords: hydrolase proteinase converting, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: SARS coronavirus (SARS-CoV); More
• Cellular location: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• Total number of polymer chains: 2
• Total formula weight: 34369.25

Authors

Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjho, A. (deposition date: 2011-03-09, release date: 2011-12-14, Last modification date: 2023-11-15)

• Primary citation: Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Shimamoto, Y.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjoh, A.; Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.; J.Med.Chem., 54:7962-7973, 2011; PubMed: 22014094; DOI: 10.1021/jm200870n

Experimental method

X-RAY DIFFRACTION (2.3 Å)