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3AO2

Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase

Summary for 3AO2
Entry DOI10.2210/pdb3ao2/pdb
Related1bl3 3AO1 3AO3 3AO4 3AO5 3OVN 3l3u
DescriptorPOL polyprotein, CADMIUM ION, CHLORIDE ION, ... (9 entities in total)
Functional Keywordsdna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein, rnaseh, fragment binding, viral protein-transferase inhibitor complex, viral protein/transferase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight37370.12
Authors
Wielens, J.,Chalmers, D.K.,Headey, S.J.,Parker, M.W.,Scanlon, M.J. (deposition date: 2010-09-20, release date: 2011-03-16, Last modification date: 2023-11-01)
Primary citationWielens, J.,Headey, S.J.,Deadman, J.J.,Rhodes, D.I.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J.
Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1
Chemmedchem, 6:258-261, 2011
Cited by
PubMed: 21275048
DOI: 10.1002/cmdc.201000483
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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