38GO

Crystal structure of MALT1 in complex with safimaltib

This is a non-PDB format compatible entry.

Summary for 38GO

• Entry DOI: 10.2210/pdb38go/pdb
• Descriptor: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: protease, inhibitor, paracaspase, allosteric, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 89796.89

Authors

Xu, R.,Grant, J. (deposition date: 2026-08-25, release date: 2026-09-02)

• Primary citation: Philippar, U.,Lu, T.,Fontan, L.,Xia, M.,Vloemans, N.,Bekkers, M.,Gaudiano, M.,Irrechukwu, O.,van den Biggelaar, D.,Perova, T.,Guimerans-Lorenzo, I.,Wnuk-Lipinska, K.,Cornelissen, I.,Van Heerden, M.,Van Der Leede, B.,Amssoms, K.,Xu, R.,Grant, J.,Trella, E.,Abraham, Y.,Kimpe, K.,Medaer, B.,Greway, T.,Snoeys, J.,Jacobs, F.,Cummings, M.D.,Sun, W.,Thuring, J.W.,Wu, T.,Gaj, S.,Verbist, B.,Connolly, P.J.,Austin, N.,Balasubramanian, S.,Kinyamu-Akunda, J.,Packman, K.,Edwards, J.P.,Elsayed, Y.,Fourneau, N.,Morschhauser, F.,Gerecitano, J.,Bussolari, J.,Melnick, A.,Attar, R.; Preclinical characterization of the potent and selective MALT1 inhibitor safimaltib in B cell lymphoma models; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.07 Å)