37ZA

Crystal structure of TP53 (89-293, Y220C)

This is a non-PDB format compatible entry.

Summary for 37ZA

• Entry DOI: 10.2210/pdb37za/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION (3 entities in total)
• Functional Keywords: p53, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46297.38

Authors

Setser, J.W. (deposition date: 2026-08-14, release date: 2026-08-26)

• Primary citation: Stuckey, J.I.,Vivat, V.,Dickson, B.M.,Setser, J.W.,Li, Y.,Cremers, C.M.,Wilson, J.E.,Peterle, D.,Engen, J.R.,Wales, T.E.,Wilcken, R.,Rohan, E.B.,Chenail, G.,Audia, J.E.,Sims, R.J.; Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.11 Å)