367D

1.2 A STRUCTURE DETERMINATION OF THE D(CG(5-BRU)ACG)2/5-BROMO-9-AMINO-DACA COMPLEX

Summary for 367D

Descriptor5'-D(*CP*GP*(BRU)P*AP*CP*G)-3', 5-BROMO-9-AMINO-N-ETHYL(DIAMINOMETHYL)ACRIDINE-4-CARBOXAMIDE, BROMIDE ION, ... (4 entities in total)
Functional Keywordsdna, double helix, complexed with drug, modified
Total number of polymer chains2
Total molecular weight4918.06
Authors
Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Cardin, C.J. (deposition date: 1997-12-19, release date: 2003-03-04, Last modification date: 2017-10-04)
Primary citation
Todd, A.K.,Adams, A.,Thorpe, J.H.,Denny, W.A.,Wakelin, L.P.G.,Cardin, C.J.
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution
J.Med.Chem., 42:536-540, 1999
PubMed: 10052960 (PDB entries with the same primary citation)
DOI: 10.1021/jm980479u
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.2 Å)
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Structure validation

Clashscore8MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution