35UI

Crystal structure of TFPI K2 domain in complex with TFPI-24 Fab fragment

35UI の概要

• エントリーDOI: 10.2210/pdb35ui/pdb
• 分子名称: TFPI-24-Fab Heavy chain, TFPI-24-Fab light chain, Tissue factor pathway inhibitor, ... (5 entities in total)
• 機能のキーワード: tissue factor pathway inhibitor, antibody, fab fragment, tfpi, kunitz domain, factor xa, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 54399.60

構造登録者

Juo, Z.S.,Mosyak, L. (登録日: 2026-05-18, 公開日: 2026-05-27)

• 主引用文献: Jin, M.,Hett, S.,Jasuja, R.,Rakhe, S.,Narula, J.,Tam, A.,Apgar, J.R.,Juo, Z.S.,Mosyak, L.,Holsti, M.,Joyce, A.,Hurst, S.,Webster, R.,Lin, L.,Stahl, M.,Pittman, D.D.,Bloom, L.; Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B; To Be Published,

実験手法

X-RAY DIFFRACTION (1.75 Å)