311D
THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2
Summary for 311D
Entry DOI | 10.2210/pdb311d/pdb |
Descriptor | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 5-AMIDINO-2-[2-(4-AMIDINOPHENYL)-5-BENZIMIDAZOLYL]BENZIMIDAZOLE (3 entities in total) |
Functional Keywords | b-dna, double helix, complexed with drug, dna |
Total number of polymer chains | 2 |
Total formula weight | 7721.22 |
Authors | Clark, G.R.,Boykin, D.W.,Czarny, A.,Neidle, S. (deposition date: 1997-02-04, release date: 1997-02-11, Last modification date: 2024-02-21) |
Primary citation | Clark, G.R.,Boykin, D.W.,Czarny, A.,Neidle, S. Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition. Nucleic Acids Res., 25:1510-1515, 1997 Cited by PubMed: 9162901DOI: 10.1093/nar/25.8.1510 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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