2ZZC

Crystal structure of NADP(H):human thioredoxin reductase I

2ZZC の概要

• エントリーDOI: 10.2210/pdb2zzc/pdb
• 関連するPDBエントリー: 2ZZ0 2ZZB
• 分子名称: Thioredoxin reductase 1, cytoplasmic, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: rossmann fold, alternative splicing, cytoplasm, electron transport, fad, flavoprotein, nadp, nucleus, oxidoreductase, phosphoprotein, polymorphism, redox-active center, selenium, selenocysteine, transport
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm . Isoform 4: Cytoplasm. Isoform 5: Cytoplasm: Q16881
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 232077.13

構造登録者

Lo, Y.C.,Ko, T.P.,Wang, A.H.J. (登録日: 2009-02-09, 公開日: 2009-08-18, 最終更新日: 2023-11-01)

• 主引用文献: Lo, Y.C.,Ko, T.P.,Su, W.C.,Su, T.L.,Wang, A.H.J.; Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1.; J.Inorg.Biochem., 103:1082-1092, 2009; PubMed: 19525010; DOI: 10.1016/j.jinorgbio.2009.05.006

実験手法

X-RAY DIFFRACTION (2.6 Å)