2ZYE
Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography
Summary for 2ZYE
Entry DOI | 10.2210/pdb2zye/pdb |
Related | 1hpx |
Related PRD ID | PRD_000562 |
Descriptor | protease, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide (3 entities in total) |
Functional Keywords | hiv-1 protease, acid protease, homodimer, hydrolase, multifunctional enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22149.19 |
Authors | Adachi, M.,Ohhara, T.,Tamada, T.,Okazaki, N.,Kuroki, R. (deposition date: 2009-01-20, release date: 2009-03-24, Last modification date: 2024-05-29) |
Primary citation | Adachi, M.,Ohhara, T.,Kurihara, K.,Tamada, T.,Honjo, E.,Okazaki, N.,Arai, S.,Shoyama, Y.,Kimura, K.,Matsumura, H.,Sugiyama, S.,Adachi, H.,Takano, K.,Mori, Y.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Kuroki, R. Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography. Proc.Natl.Acad.Sci.USA, 2009 Cited by PubMed: 19273847DOI: 10.1073/pnas.0809400106 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report