2ZYE

Structure of HIV-1 Protease in Complex with Potent Inhibitor KNI-272 Determined by Neutron Crystallography

Summary for 2ZYE

• Entry DOI: 10.2210/pdb2zye/pdb
• Related: 1hpx
• Related PRD ID: PRD_000562
• Descriptor: protease, (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide (3 entities in total)
• Functional Keywords: hiv-1 protease, acid protease, homodimer, hydrolase, multifunctional enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22149.19

Authors

Adachi, M.,Ohhara, T.,Tamada, T.,Okazaki, N.,Kuroki, R. (deposition date: 2009-01-20, release date: 2009-03-24, Last modification date: 2021-11-10)

• Primary citation: Adachi, M.,Ohhara, T.,Kurihara, K.,Tamada, T.,Honjo, E.,Okazaki, N.,Arai, S.,Shoyama, Y.,Kimura, K.,Matsumura, H.,Sugiyama, S.,Adachi, H.,Takano, K.,Mori, Y.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Kuroki, R.; Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.; Proc.Natl.Acad.Sci.USA, 2009; PubMed: 19273847; DOI: 10.1073/pnas.0809400106

Experimental method

NEUTRON DIFFRACTION (1.9 Å)