2ZY0

Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist compound and a coactivator peptide

2ZY0 の概要

• エントリーDOI: 10.2210/pdb2zy0/pdb
• 関連するPDBエントリー: 1FBY 1MV9 1MVC 2ZXZ
• 分子名称: Retinoic acid receptor RXR-alpha, GRIP1 from Nuclear receptor coactivator 2, 4-[2-(1,1,3,3-tetramethyl-2,3-dihydro-1H-1,3-benzodisilol-5-yl)-1,3-dioxolan-2-yl]benzoic acid, ... (4 entities in total)
• 機能のキーワード: transcription regulation, nuclear receptor, structural genomics, structural genomics consortium for research on gene expression, sgcges, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : P19793 Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57669.01

構造登録者

Sato, Y.,Antony, P.,Rochel, N.,Moras, D.,Structural Genomics Consortium for Research on Gene Expression (SGCGES) (登録日: 2009-01-09, 公開日: 2009-08-11, 最終更新日: 2023-11-01)

• 主引用文献: Lippert, W.P.,Burschka, C.,Gotz, K.,Kaupp, M.,Ivanova, D.,Gaudon, C.,Sato, Y.,Antony, P.,Rochel, N.,Moras, D.,Gronemeyer, H.,Tacke, R.; Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology; Chemmedchem, 4:1143-1152, 2009; PubMed: 19496083; DOI: 10.1002/cmdc.200900090

実験手法

X-RAY DIFFRACTION (2.9 Å)