2ZV2

Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609

2ZV2 の概要

• エントリーDOI: 10.2210/pdb2zv2/pdb
• 分子名称: Calcium/calmodulin-dependent protein kinase kinase 2, 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (3 entities in total)
• 機能のキーワード: calcium/calmodulin-dependent protein kinase kinase 2, beta, sto-609, camkk2, e.c.2.7.11.17, phosphorylation, ampkk, metabolism, atp-binding, kinase, calmodulin-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus (By similarity): Q96RR4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33921.95

構造登録者

Yoshikawa, S.,Kukimoto-niino, M.,Shirouzu, M.,Suzuki, A.,Lee, S.,Minokoshi, Y.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2008-10-31, 公開日: 2009-11-03, 最終更新日: 2023-11-01)

• 主引用文献: Kukimoto-Niino, M.,Yoshikawa, S.,Takagi, T.,Ohsawa, N.,Tomabechi, Y.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S.; Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609; J.Biol.Chem., 286:22570-22579, 2011; PubMed: 21504895; DOI: 10.1074/jbc.M111.251710

実験手法

X-RAY DIFFRACTION (2.4 Å)