2ZU2

complex structure of CoV 229E 3CL protease with EPDTC

2ZU2 の概要

• エントリーDOI: 10.2210/pdb2zu2/pdb
• 関連するPDBエントリー: 2ZTX 2ZTY 2ZTZ 2ZU1 2ZU3 2ZU4 2ZU5
• 分子名称: 3C-like proteinase, (4S)-2-METHYL-2,4-PENTANEDIOL, zinc(II)hydrogensulfide, ... (4 entities in total)
• 機能のキーワード: protease-inhibitor complex, hydrolase, metal-binding, protease, thiol protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human coronavirus (HCoV-229E)
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66548.44

構造登録者

Lee, C.C.,Wang, A.H.-J. (登録日: 2008-10-12, 公開日: 2009-01-13, 最終更新日: 2023-11-01)

• 主引用文献: Lee, C.C.,Kuo, C.J.,Ko, T.P.,Hsu, M.F.,Tsui, Y.C.,Chang, S.C.,Yang, S.,Chen, S.J.,Chen, H.C.,Hsu, M.C.,Shih, S.R.,Liang, P.H.,Wang, A.H.-J.; Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds; J.Biol.Chem., 284:7646-7655, 2009; PubMed: 19144641; DOI: 10.1074/jbc.M807947200

実験手法

X-RAY DIFFRACTION (1.8 Å)