2ZP0

Human factor viia-tissue factor complexed with benzylsulfonamide-D-ile-gln-P-aminobenzamidine

2ZP0 の概要

• エントリーDOI: 10.2210/pdb2zp0/pdb
• 分子名称: Factor VII light chain, Factor VII heavy chain, Tissue factor, ... (8 entities in total)
• 機能のキーワード: serine protease, blood coagulation, cleavage on pair of basic residues, disease mutation, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, protease, zymogen, lipoprotein, membrane, palmitate, transmembrane, hydrolase-blood clotting complex, hydrolase/blood clotting
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P08709 P08709; Membrane; Single-pass type I membrane protein: P13726
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 71537.41

構造登録者

Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H. (登録日: 2008-06-20, 公開日: 2008-07-15, 最終更新日: 2023-11-15)

• 主引用文献: Kadono, S.,Sakamoto, A.,Kikuchi, Y.,Oh-eda, M.,Yabuta, N.,Koga, T.,Hattori, K.,Shiraishi, T.,Haramura, M.,Kodama, H.,Esaki, T.,Sato, H.,Watanabe, S.,Itoh, S.,Ohta, M.,Kozono, T.; Peptide Mimetic Factor VIIa Inhibitor: Importance of Hydrophilic Pocket in S2 Site to Improve Selectivity aganist Thrombin; LETT.DRUG DES.DISCOVERY, 2:177-181, 2005

実験手法

X-RAY DIFFRACTION (2.7 Å)