2ZNT

Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, dysiherbaine

Summary for 2ZNT

• Entry DOI: 10.2210/pdb2znt/pdb
• Related: 2ZNS 2ZNU
• Descriptor: Glutamate receptor, ionotropic kainate 1, (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• Functional Keywords: glur5, kainate receptor, ligand-binding core, amino acid, agonist, dysiherbaine, alternative splicing, cell junction, glycoprotein, ion transport, ionic channel, membrane, phosphoprotein, polymorphism, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P39086
• Total number of polymer chains: 1
• Total formula weight: 29788.40

Authors

Unno, M.,Sasaki, M.,Ikeda-Saito, M. (deposition date: 2008-05-01, release date: 2009-05-05, Last modification date: 2023-11-01)

• Primary citation: Unno, M.,Shinohara, M.,Takayama, K.,Tanaka, H.,Teruya, K.,Doh-Ura, K.,Sakai, R.,Sasaki, M.,Ikeda-Saito, M.; Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.; J.Mol.Biol., 413:667-683, 2011; PubMed: 21893069; DOI: 10.1016/j.jmb.2011.08.043

Experimental method

X-RAY DIFFRACTION (1.6 Å)