2ZNH

Crystal Structure of a Domain-Swapped Serpin Dimer

Summary for 2ZNH

Entry DOI	10.2210/pdb2znh/pdb
Descriptor	Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	domain-swap, blood coagulation, disease mutation, glycoprotein, heparin-binding, protease inhibitor, secreted, serine protease inhibitor, thrombophilia, blood clotting
Biological source	Homo sapiens (Human)
Cellular location	Secreted, extracellular space: P01008
Total number of polymer chains	2
Total formula weight	100626.18
Authors	Yamasaki, M.,Huntington, J.A. (deposition date: 2008-04-25, release date: 2008-10-21, Last modification date: 2023-11-01)
Primary citation	Yamasaki, M.,Li, W.,Johnson, D.J.,Huntington, J.A. Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization Nature, 455:1255-1258, 2008 Cited by PubMed: 18923394 DOI: 10.1038/nature07394 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation