2ZMJ
Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism
Summary for 2ZMJ
Entry DOI | 10.2210/pdb2zmj/pdb |
Related | 2ZMH 2ZMI |
Descriptor | Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-{(1S,2E,5R)-5-hydroxy-1-methyl-6-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]hex-2-en-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total) |
Functional Keywords | nuclear receptor-antagonist complex, dna-binding, metal-binding, nucleus, phosphoprotein, receptor, transcription, transcription regulation, zinc, zinc-finger, activator |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Nucleus: P13053 Nucleus (By similarity): A1L0Z0 |
Total number of polymer chains | 2 |
Total formula weight | 32700.75 |
Authors | Nakabayashi, M.,Yamada, S.,Tanaka, T.,Igarashi, M.,Yoshimoto, N.,Ikura, T.,Ito, N.,Makishima, M.,Tokiwa, H.,DeLuca, H.F.,Shimizu, M. (deposition date: 2008-04-19, release date: 2008-09-02, Last modification date: 2024-03-13) |
Primary citation | Nakabayashi, M.,Yamada, S.,Yoshimoto, N.,Tanaka, T.,Igarashi, M.,Ikura, T.,Ito, N.,Makishima, M.,Tokiwa, H.,DeLuca, H.F.,Shimizu, M. Crystal structures of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and partial agonism J.Med.Chem., 51:5320-5329, 2008 Cited by PubMed: 18710208DOI: 10.1021/jm8004477 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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