2ZMH

Crystal Structure of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and/or Partial Agonism

2ZMH の概要

• エントリーDOI: 10.2210/pdb2zmh/pdb
• 関連するPDBエントリー: 2ZMI 2ZMJ
• 分子名称: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-{(1R,2E,4R)-4-hydroxy-1-methyl-4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]but-2-en-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• 機能のキーワード: nuclear receptor-antagonist complex, dna-binding, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, zinc, zinc-finger, activator
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Nucleus: P13053; Nucleus (By similarity): A1L0Z0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32672.69

構造登録者

Nakabayashi, M.,Yamada, S.,Tanaka, T.,Igarashi, M.,Yoshimoto, N.,Ikura, T.,Ito, N.,Makishima, M.,Tokiwa, H.,DeLuca, H.F.,Shimizu, M. (登録日: 2008-04-18, 公開日: 2008-09-02, 最終更新日: 2024-03-13)

• 主引用文献: Nakabayashi, M.,Yamada, S.,Yoshimoto, N.,Tanaka, T.,Igarashi, M.,Ikura, T.,Ito, N.,Makishima, M.,Tokiwa, H.,DeLuca, H.F.,Shimizu, M.; Crystal structures of rat vitamin d receptor bound to adamantyl vitamin d analogs: structural basis for vitamin d receptor antagonism and partial agonism; J.Med.Chem., 51:5320-5329, 2008; PubMed: 18710208; DOI: 10.1021/jm8004477

実験手法

X-RAY DIFFRACTION (2.1 Å)