2ZLA

2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure

2ZLA の概要

• エントリーDOI: 10.2210/pdb2zla/pdb
• 関連するPDBエントリー: 2ZL9 2ZLC
• 分子名称: Vitamin D3 receptor, Coactivator peptide DRIP, (1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethoxy)-9,10-secoestra-5,7,16-triene-1,3-diol, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, dna-binding, metal-binding, nucleus, phosphoprotein, receptor, transcription, transcription regulation, zinc, zinc-finger, hormone
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Nucleus: P13053
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32660.66

構造登録者

Shimizu, M.,Miyamoto, Y.,Nakabayashi, M.,Masuno, H.,Ikura, T.,Ito, N. (登録日: 2008-04-04, 公開日: 2008-06-24, 最終更新日: 2023-11-01)

• 主引用文献: Shimizu, M.,Miyamoto, Y.,Takaku, H.,Matsuo, M.,Nakabayashi, M.,Masuno, H.,Udagawa, N.,DeLuca, H.F.,Ikura, T.,Ito, N.; 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure; Bioorg.Med.Chem., 16:6949-6964, 2008; PubMed: 18539034; DOI: 10.1016/j.bmc.2008.05.043

実験手法

X-RAY DIFFRACTION (2 Å)