2ZK6
Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with C8-BODIPY
Summary for 2ZK6
Entry DOI | 10.2210/pdb2zk6/pdb |
Related | 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 |
Descriptor | Peroxisome proliferator-activated receptor gamma, difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron (3 entities in total) |
Functional Keywords | anti parallel helix sandwich, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65869.91 |
Authors | Waku, T.,Shiraki, T.,Oyama, T.,Fujimoto, Y.,Morikawa, K. (deposition date: 2008-03-12, release date: 2009-02-24, Last modification date: 2023-11-01) |
Primary citation | Waku, T.,Shiraki, T.,Oyama, T.,Maebara, K.,Nakamori, R.,Morikawa, K. The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29:3395-3407, 2010 Cited by PubMed: 20717101DOI: 10.1038/emboj.2010.197 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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