2ZI8
Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)
Summary for 2ZI8
Entry DOI | 10.2210/pdb2zi8/pdb |
Related | 2ZF1 |
Descriptor | PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC, FE (II) ION, 3,4-dihydroxy-9,10-secoandrosta-1(10),2,4-triene-9,17-dione, ... (4 entities in total) |
Functional Keywords | dhsa, hsac, extradiol dioxygenase, mycobacterium tuberculosis, aromatic hydrocarbons catabolism, iron, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 68001.10 |
Authors | D'Angelo, I.,Yam, K.C.,Eltis, L.D.,Strynadka, N. (deposition date: 2008-02-13, release date: 2009-02-24, Last modification date: 2023-11-01) |
Primary citation | Yam, K.C.,D'Angelo, I.,Kalscheuer, R.,Zhu, H.,Wang, J.X.,Snieckus, V.,Ly, L.H.,Converse, P.J.,Jacobs, W.R.,Strynadka, N.,Eltis, L.D. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. Plos Pathog., 5:e1000344-e1000344, 2009 Cited by PubMed: 19300498DOI: 10.1371/journal.ppat.1000344 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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