2ZI8

Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA)

2ZI8 の概要

• エントリーDOI: 10.2210/pdb2zi8/pdb
• 関連するPDBエントリー: 2ZF1
• 分子名称: PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC, FE (II) ION, 3,4-dihydroxy-9,10-secoandrosta-1(10),2,4-triene-9,17-dione, ... (4 entities in total)
• 機能のキーワード: dhsa, hsac, extradiol dioxygenase, mycobacterium tuberculosis, aromatic hydrocarbons catabolism, iron, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68001.10

構造登録者

D'Angelo, I.,Yam, K.C.,Eltis, L.D.,Strynadka, N. (登録日: 2008-02-13, 公開日: 2009-02-24, 最終更新日: 2023-11-01)

• 主引用文献: Yam, K.C.,D'Angelo, I.,Kalscheuer, R.,Zhu, H.,Wang, J.X.,Snieckus, V.,Ly, L.H.,Converse, P.J.,Jacobs, W.R.,Strynadka, N.,Eltis, L.D.; Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.; Plos Pathog., 5:e1000344-e1000344, 2009; PubMed: 19300498; DOI: 10.1371/journal.ppat.1000344

実験手法

X-RAY DIFFRACTION (2.2 Å)