2ZHT
Crystal structure of BACE1 at pH 4.5
Summary for 2ZHT
| Entry DOI | 10.2210/pdb2zht/pdb |
| Related | 2ZHR 2ZHS 2ZHU 2ZHV |
| Descriptor | Beta-secretase 1 (2 entities in total) |
| Functional Keywords | ph 4.5, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
| Total number of polymer chains | 1 |
| Total formula weight | 45900.50 |
| Authors | Shimizu, H.,Nukina, N. (deposition date: 2008-02-08, release date: 2008-04-22, Last modification date: 2023-11-01) |
| Primary citation | Shimizu, H.,Tosaki, A.,Kaneko, K.,Hisano, T.,Sakurai, T.,Nukina, N. Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production Mol.Cell.Biol., 28:3663-3671, 2008 Cited by PubMed: 18378702DOI: 10.1128/MCB.02185-07 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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