2ZHR
Crystal structure of BACE1 in complex with OM99-2 at pH 5.0
Summary for 2ZHR
| Entry DOI | 10.2210/pdb2zhr/pdb |
| Related | 2ZHS 2ZHT 2ZHU 2ZHV |
| Related PRD ID | PRD_000290 |
| Descriptor | Beta-secretase 1, inhibitor OM99-2 (3 entities in total) |
| Functional Keywords | om99-2 complex, ph 5.0, aspartyl protease, glycoprotein, membrane, protease, transmembrane, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
| Total number of polymer chains | 4 |
| Total formula weight | 93586.98 |
| Authors | Shimizu, H.,Nukina, N. (deposition date: 2008-02-08, release date: 2008-04-22, Last modification date: 2023-11-15) |
| Primary citation | Shimizu, H.,Tosaki, A.,Kaneko, K.,Hisano, T.,Sakurai, T.,Nukina, N. Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production Mol.Cell.Biol., 28:3663-3671, 2008 Cited by PubMed: 18378702DOI: 10.1128/MCB.02185-07 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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