2ZED
Crystal structure of the human glutaminyl cyclase mutant S160A at 1.7 angstrom resolution
Summary for 2ZED
Entry DOI | 10.2210/pdb2zed/pdb |
Related | 2AFM 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP |
Descriptor | Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hydrogen bond network, glutaminyl cyclase, pyroglutamate, site-directed mutagenesis, proton transfer, acyltransferase, glycoprotein, metal-binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : Q16769 |
Total number of polymer chains | 2 |
Total formula weight | 75405.74 |
Authors | Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H. (deposition date: 2007-12-12, release date: 2008-04-22, Last modification date: 2023-11-01) |
Primary citation | Huang, K.F.,Wang, Y.R.,Chang, E.C.,Chou, T.L.,Wang, A.H. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. Biochem.J., 411:181-190, 2008 Cited by PubMed: 18072935DOI: 10.1042/BJ20071073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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