2ZC0

Crystal structure of an archaeal alanine:glyoxylate aminotransferase

2ZC0 の概要

• エントリーDOI: 10.2210/pdb2zc0/pdb
• 分子名称: Alanine glyoxylate transaminase, ZINC ION, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: alanine:glyoxylate aminotransferase, archaea, thermococcus litoralis, transferase
• 由来する生物種: Thermococcus litoralis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 182441.39

構造登録者

Sakuraba, H.,Yoneda, K.,Tsuge, H.,Ohshima, T. (登録日: 2007-10-31, 公開日: 2008-06-17, 最終更新日: 2024-03-13)

主引用文献

Sakuraba, H.,Yoneda, K.,Takeuchi, K.,Tsuge, H.,Katunuma, N.,Ohshima, T.
Structure of an archaeal alanine:glyoxylate aminotransferase
Acta Crystallogr.,Sect.D, 64:696-699, 2008

PubMed Abstract: The crystal structure of a novel alanine:glyoxylate aminotransferase from the hyperthermophilic archaeon Thermococcus litoralis was determined at 2.3 A resolution. The asymmetric unit contains four homologous subunits and the functional tetramer is generated by noncrystallographic 222 symmetry. Although the main-chain coordinates of the monomer of the Thermococcus litoralis enzyme showed a high degree of similarity to those of aspartate aminotransferase from Thermus thermophilus HB8, the amino-acid residues involved in substrate binding in the aspartate aminotransferase are only partially conserved in the Thermococcus litoralis enzyme. This may account for the difference in the substrate specificities of the two enzymes.

PubMed: 18560158
DOI: 10.1107/S0907444908006732

実験手法

X-RAY DIFFRACTION (2.3 Å)