2ZBZ

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D3

2ZBZ の概要

• エントリーDOI: 10.2210/pdb2zbz/pdb
• 関連するPDBエントリー: 2ZBX 2ZBY
• 分子名称: Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: p450, beta prism, heme, iron, metal-binding, monooxygenase, oxidoreductase
• 由来する生物種: Streptomyces griseolus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46024.86

構造登録者

Sugimoto, H.,Shinkyo, R.,Hayashi, K.,Yoneda, S.,Yamada, M.,Kamakura, M.,Ikushiro, S.,Shiro, Y.,Sakaki, T. (登録日: 2007-10-30, 公開日: 2008-04-08, 最終更新日: 2023-11-01)

• 主引用文献: Sugimoto, H.,Shinkyo, R.,Hayashi, K.,Yoneda, S.,Yamada, M.,Kamakura, M.,Ikushiro, S.,Shiro, Y.,Sakaki, T.; Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1alpha,25-Dihydroxyvitamin D3; Biochemistry, 47:4017-4027, 2008; PubMed: 18314962; DOI: 10.1021/bi7023767

実験手法

X-RAY DIFFRACTION (1.9 Å)