2Z9T

Crystal structure of the human beta-2 microglobulin mutant W60G

Summary for 2Z9T

• Entry DOI: 10.2210/pdb2z9t/pdb
• Descriptor: Beta-2-microglobulin (2 entities in total)
• Functional Keywords: beta-2-microglobulin, tryptophan, glycine, amyloidosis, dra, beta fibrils, disease mutation, glycation, glycoprotein, immune response, immunoglobulin domain, mhc i, pyrrolidone carboxylic acid, secreted, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P61769
• Total number of polymer chains: 1
• Total formula weight: 11750.20

Authors

Ricagno, S.,Bolognesi, M.,Bellotti, V.,Corazza, A.,Rennella, E.,Gural, D.,Mimmi, M.C.,Betto, E.,Pucillo, C.,Fogolari, F.,Viglino, P.,Raimondi, S.,Giorgetti, S.,Bolognesi, B.,Merlini, G.,Stoppini, M. (deposition date: 2007-09-26, release date: 2008-04-22, Last modification date: 2023-11-01)

• Primary citation: Esposito, G.,Ricagno, S.,Corazza, A.,Rennella, E.,Gumral, D.,Mimmi, M.C.,Betto, E.,Pucillo, C.E.M.,Fogolari, F.,Viglino, P.,Raimondi, S.,Giorgetti, S.,Bolognesi, B.,Merlini, G.,Stoppini, M.,Bolognesi, M.,Bellotti, V.; The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties; J.Mol.Biol., 378:885-895, 2008; PubMed: 18395224; DOI: 10.1016/j.jmb.2008.03.002

Experimental method

X-RAY DIFFRACTION (1.8 Å)