2Z9T

Crystal structure of the human beta-2 microglobulin mutant W60G

2Z9T の概要

• エントリーDOI: 10.2210/pdb2z9t/pdb
• 分子名称: Beta-2-microglobulin (2 entities in total)
• 機能のキーワード: beta-2-microglobulin, tryptophan, glycine, amyloidosis, dra, beta fibrils, disease mutation, glycation, glycoprotein, immune response, immunoglobulin domain, mhc i, pyrrolidone carboxylic acid, secreted, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P61769
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11750.20

構造登録者

Ricagno, S.,Bolognesi, M.,Bellotti, V.,Corazza, A.,Rennella, E.,Gural, D.,Mimmi, M.C.,Betto, E.,Pucillo, C.,Fogolari, F.,Viglino, P.,Raimondi, S.,Giorgetti, S.,Bolognesi, B.,Merlini, G.,Stoppini, M. (登録日: 2007-09-26, 公開日: 2008-04-22, 最終更新日: 2023-11-01)

• 主引用文献: Esposito, G.,Ricagno, S.,Corazza, A.,Rennella, E.,Gumral, D.,Mimmi, M.C.,Betto, E.,Pucillo, C.E.M.,Fogolari, F.,Viglino, P.,Raimondi, S.,Giorgetti, S.,Bolognesi, B.,Merlini, G.,Stoppini, M.,Bolognesi, M.,Bellotti, V.; The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties; J.Mol.Biol., 378:885-895, 2008; PubMed: 18395224; DOI: 10.1016/j.jmb.2008.03.002

実験手法

X-RAY DIFFRACTION (1.8 Å)