2Z9J

Complex structure of SARS-CoV 3C-like protease with EPDTC

2Z9J の概要

• エントリーDOI: 10.2210/pdb2z9j/pdb
• 関連するPDBエントリー: 2Z9G 2Z9K 2Z9L
• 分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, zinc(II)hydrogensulfide, ... (4 entities in total)
• 機能のキーワード: complex, atp-binding, cytoplasm, endonuclease, exonuclease, helicase, hydrolase, membrane, metal-binding, nuclease, nucleotide-binding, nucleotidyltransferase, protease, ribosomal frameshift, rna replication, rna-binding, rna-directed rna polymerase, thiol protease, transferase, transmembrane, zinc, zinc-finger
• 由来する生物種: SARS coronavirus
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68328.92

構造登録者

Lee, C.C.,Wang, A.H. (登録日: 2007-09-20, 公開日: 2007-12-25, 最終更新日: 2023-11-01)

• 主引用文献: Lee, C.C.,Kuo, C.J.,Hsu, M.F.,Liang, P.H.,Fang, J.M.,Shie, J.J.,Wang, A.H.; Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors.; Febs Lett., 581:5454-5458, 2007; PubMed: 17981158; DOI: 10.1016/j.febslet.2007.10.048

実験手法

X-RAY DIFFRACTION (1.95 Å)